Melanin: Aging of the Skin and Skin Cancer

"Ultraviolet (UV) radiation is responsible for 90%American Academy of Dermatology does not
of the visible signs of aging on the skin of whites,"recommend their use.UV-B radiation, which is
says Dr. Michael J. Martin, former Assistant Clinicalpartially filtered by the ozone, penetrates the skin
Professor in the Dept. of Epidemiology andto the bottom layer of the epidermis where the
Biostatistics at University of California, Sanbasal cells are produced. UV-B can break the
Francisco.Blacks' skin, however, ages muchmolecular bonds, disturbing the dividing cells and
slower.Why are most dark-skinned blacksaltering their structure. Compared with UV-A,
protected from harmful UV rays? BecauseUV-B is responsible for most of DNAs damage. It
compared to whites, blacks possess morealso causes most sunburns. During a sunburn the
melanin, the pigment that gives skin itsreddening of the skin, erythema, is caused by
color.MelaninMelanin offers protection against UVdilation of capillaries.More UV-B is present during
rays for blacks and other dark-skinned people.summer months between 10 a.m. and 4 p.m. and
Conversely, fair-skinned people are much lessat latitudes closer to the equator. Furthermore, at
protected and more susceptible to skin cancer.high altitudes the air is thinner and cleaner, so
Furthermore, albinos' skin offers noUV-B radiation is more abundant.UV-C, which is
protection.Although blacks' skin produces moregenerally filtered by the ozone, has the shortest
melanin than whites', all skin has the same numberwavelength and the most energy, or intensity. It
of melanocytes, the cells that manufacture thecan sterilize hospital equipment and kill bacteria.In
melanin.Melanocytes manufacture melanin from anaddition, UV light that reaches the earth is
amino acid, tyrosin, with the help of an enzyme,scattered in all directions, and up to 85% is
tyrosinase. In the bottom layer of the epidermisreflected from surfaces.The Theory of Melanin
above the dermis, UV light stimulates thefor Environmental AdaptationOriginally, people of a
production of melanin in the form of insolubleparticular race resided in a particular area. As time
melanosomes. These surround the epidermal cells,went on, their skin adapted to the environment.
which move up to the surface of the skin. TheFor instance, people who lived geographically close
result is a tan.Blacks' skin produce more melanin,to the equator had darker skin, and people who
even in the absence of sunlight, and their type oflived far from the equator had lighter skin.In
melanin, eumelanin, is more effective at blockingScotland, which lies at a northern latitude,
solar rays. However, white skin produces melanindescendants of the Britons have white skin. When
only in the presence of sunlight and after the UVtheir skin is exposed to the meager sunlight, the
rays have penetrated the lower portion of thescant amount of melanin their skin produces is
epidermis and have caused skin damage."Melaninunable to block the sunlight. Therefore, their
also functions as an excellent free radicalbodies are able to make Vitamin D with the help
scavenger. It affects the delicately designed lipidsof sunlight. Vitamin D, a vitamin found in fish oil, is
that hold moisture in the stratum corneum (thenecessary to prevent rickets, a bone disease
outermost layer of the epidermis). If the skincaused by too little calcium.In contrast, in Africa,
loses its moisture, it becomes rigid and cracks,"which is near the equator, blacks require intense
says Sergio Nacht, PhD., Senior Vice-President ofsunlight to penetrate their dark skin to make
Enhanced Derm Technologies, Inc. in RedwoodVitamin D. This is all well and good. However,
City.UV Radiation and SkinUV-A has the longestwhen blacks lived in England during the Industrial
wavelength, is not filtered by the ozone andRevolution, they were the first to develop
passes through glass. It reaches the earth all yearsymptoms of rickets, such as retarded growth,
long and the amount is comparatively stable. Itbowed legs and fractures because not enough
can penetrate the skin down to the dermis,sunlight was available.Fortunately, in 1930, Vitamin
beneath the four layers of epidermis. It isD was discovered and dispensed as a supplement
responsible for most of the visible signs of aging,to add to the diet.On the other hand, the skin of
due to damage to collagen and elastic fibers ofwhites in Australia are in complete opposition to
the connective tissue of the dermis.UV-A radiationtheir climate. Consequently, intense UV radiation
also plays a role in the development of sunburnshas been the major cause of skin damage and
and skin cancer. Tanning salon lamps emit a largeskin cancer Down Under.
amount of UV-A rays to generate tans, so the